Overdose deaths involving prescription opioids killed more than 17,000 Americans in 2017, marking a five-fold increase since 1999. High prescribing rates of opioid analgesics have been a substantial contributor to prescription opioid misuse, dependence, overdose and heroin use. There was recognition approximately ten years ago that opioid prescribing patterns were contributing to this startling increase in negative opioid-related outcomes, and federal actions, including Medicare reimbursement reform and regulatory actions, were initiated to restrict opioid prescribing. The current manuscript is a description (...) of those actions, the effect of those actions on opioid prescribing and related patient outcomes. We also describe our proposal of methods of expanding these efforts as an important piece to further reduce opioid-related misuse, dependence, and overdose death. (shrink)

We present Woodin's proof that if there exists a measurable Woodin cardinal δ, then there is a forcing extension satisfying all $\Sigma _{2}^{2}$ sentences ϕ such that CH + ϕ holds in a forcing extension of V by a partial order in V δ . We also use some of the techniques from this proof to show that if there exists a stationary limit of stationary limits of Woodin cardinals, then in a homogeneous forcing extension there is an elementary embedding (...) j: V → M with critical point $\omega _{1}^{V}$ such that M is countably closed in the forcing extension. (shrink)

Previous work suggests that threat-related stimuli are stored to a greater degree in working memory compared to neutral stimuli. However, most of this research has focused on stimuli with physically salient threat attributes, failing to account for how a “neutral” stimulus that has acquired threat-related associations through differential aversive conditioning influences working memory. The current study examined how differentially conditioned safe and threat stimuli are stored in working memory relative to a novel, non-associated stimuli. Participants completed a differential fear conditioning (...) task followed by a change detection task consisting of three conditions across two loads. Results revealed individuals successfully learned to distinguishing CS+ from CS– conditions during the differential aversive conditioning task. Our working memory outcomes indicated successful load manipulation effects, but no statistically significant differences in accuracy, response time, or Pashler’s K measures of working memory capacity between CS+, CS–, or N conditions. However, we observed significantly reduced RT difference scores for the CS+ compared to CS– condition, indicating greater RT differences between the CS+ and N condition vs. the CS– and N condition. These findings suggest that differentially conditioned stimuli have little impact on behavioral outcomes of working memory compared to novel stimuli that had not been associated with previous safe of aversive outcomes, at least in healthy populations. (shrink)

The way language as a human faculty has evolved is a question that preoccupies researchers from a wide spread of disciplines. In this book, a team of writers has been brought together to examine the evolution of language from a variety of such standpoints, including language's genetic basis, the anthropological context of its appearance, its formal structure, its relation to systems of cognition and thought, as well as its possible evolutionary antecedents. The book includes Hauser, Chomsky, and Fitch's seminal and (...) provocative essay on the subject, 'The Faculty of Language,' and charts the progress of research in this active and highly controversial field since its publication in 2002. This timely volume will be welcomed by researchers and students in a number of disciplines, including linguistics, evolutionary biology, psychology, and cognitive science. (shrink)

The presence of temporal adjectives in possessive nominals like John's former car creates two interpretations. On one reading, the temporal adjective modifies the common noun (N-modifying reading). On the other, it modifies the possession relation (POSS-modifying reading). An explanation for this behavior is offered that appeals to what occurs in possessive sentences like John has a former car (N-modifying reading) and John formerly had a car (POSS-modifying reading). In the sentential cases, the source of two readings is two distinct, modifiable (...) phrases. Given the parallels, we propose a structure for possessive nominals analogous to that of possessive clauses. Specifically, we argue that such nominals include a locative small-clause structure, following Freeze (1992), and we explain the ambiguity structurally, as a simple matter of where temporal adjectives attach (NP vs. PP). We show that this analysis provides a straightforward basis for the semantic composition of possessive nominals. (shrink)

In 1914, James Leuba, a psychologist at Bryn Mawr, conducted several surveys of scientists and college students regarding their religious beliefs, publishing his findings in a 1916 book titled The Belief in God and Immortality. Among scientists generally, 41.8 percent indicated they were believers in a personal God (defined as a being to whom one could pray, expecting a response), whereas 41.5 percent expressed disbelief in such a God and 16.7 percent declared themselves to be agnostic. Among elite scientists (those (...) with an asterisk by their names in James McKean Cattell's American Men of Science), the percentage of believers was lower, at 31.6 percent. Among elite biologists, the subset who believed in God was even smaller—16.9 percent. In 1996 and 1998, Edward Larson and Larry Witham replicated Leuba's study, publishing their findings in the April 23, 1997, and July 23, 1998, issues of Nature. Their surveys revealed that of all scientists questioned, 39.3 percent professed belief in a personal God, about the same as in the 1914 study. However, among elite scientists—now defined as members of the National Academy of Sciences—the proportion who were believers had plummeted to 7 percent, with biologists showing the least religious conviction at 5.5 percent. In the general population of the United States, some 86 percent profess belief in the existence of a personal God, according to a 1999 Gallup poll. These figures dramatically indicate the great no-mans land separating the religious convictions of ordinary citizens from those of the scientific community, especially its leading members. This dissensus has fueled many of the bitter battles recently fought over evolution and stem cells and has ignited explosive devices laid along several political byways. (shrink)

Saeculum: Gedenkschrift für Heinrich Otten anlässlich seines 100. Geburtstags. Edited by Andreas Müller-Karpe; Elisabeth Rieken; and Walter Sommerfeld. Studien zu den Boǧazköy-Texten, vol. 58. Wiesbaden: Harrassowitz Verlag, 2015. Pp. xi + 316, illus. €84.

While it seems to be evident that the vision of the eternal return of the same is the solution to the riddle mentioned in "On the vision and the riddle," exactly what constitutes the riddle is anything but clear. Li ke all good riddles the solution demands a paradigm shift. Nietzsche's riddle is solved by a radical rethinking of the concept of time, from a straight line to a circle. I give a detailed account of how Nietzsche's riddle is formulated (...) in such a way tha t the eternal return of the same is the only possible solution. (shrink)

Knowledge and expertise -- Knowledge and action -- The nature of professional action in urban planning.

What does it mean to take the Bible seriously? This introductory book explores how Scripture itself gives us the resources to read it wisely. First, it looks at the basic questions of reading in context--historical, literary, and theological--and understanding the significance of the two-testament structure of the Christian Bible. Then it looks at how the Bible can itself contribute to shaping a wise doctrine of Scripture. Finally, it considers some of the many hermeneutical perspectives that contribute to reading the Bible (...) wisely. New to this revised edition are chapters addressing the significance of the Old Testament, the performative function of Scripture, and how reading Scripture actually helps form the reader. The aim throughout is to explore key questions critical to the task of reading the Bible generously, constructively, and in a comprehensible way, without oversimplifying core theological issues. (shrink)